About Me

I am a second year PhD student in the Division of Computational & Data Sciences at Washington University in St. Louis. I am interested in applying machine learning and data-driven approaches to study neurological and neuropsychiatric disorders. With my advisor, Aristeidis Sotiras, I aim to apply machine learning methods (particularly Non-Negative Matrix Factorization) to multimodal neuroimaging data in Alzheimer's Disease.

I have a background in wet lab & clinical neuroscience research. I studied biology and neuroscience at Grinnell College, as well as psychiatric research at King's College London. I have also held research assistant positions at Washington University and the National Institutes of Health.

Outside of lab, I enjoy making & listening to music, working on Python projects, playing games of all kinds, and spending time with my partner and our dogs.

Publications

Earnest, T., Shephard, E., Tye, C., McEwen, F., Woodhouse, E., Liang, H., Sheerin, F., & Bolton, P. F. (2020). Actigraph-Measured Movement Correlates of Attention-Deficit/Hyperactivity Disorder (ADHD) Symptoms in Young People with Tuberous Sclerosis Complex (TSC) with and without Intellectual Disability and Autism Spectrum Disorder (ASD). Brain Sciences, 10(8), 491. https://doi.org/10.3390/brainsci10080491
Matikainen-Ankney, B. A., Earnest, T., Ali, M., Casey, E., Wang, J. G., Sutton, A. K., Legaria, A. A., Barclay, K. M., Murdaugh, L. B., Norris, M. R., Chang, Y.-H., Nguyen, K. P., Lin, E., Reichenbach, A., Clarke, R. E., Stark, R., Conway, S. M., Carvalho, F., Al-Hasani, R., … Kravitz, A. V. (2021). An open-source device for measuring food intake and operant behavior in rodent home-cages. ELife, 10, e66173. https://doi.org/10.7554/eLife.66173
Murphy, C., Chang, Y.-H., Pareta, R., Li, J.-N., Earnest, T., Tooley, J., Vachez, Y. M., Gereau, R. W., Copits, B. A., Kravitz, A. V., & Creed, M. C. (2021). Modeling features of addiction with an oral oxycodone self-administration paradigm. BioRxiv, 2021.02.08.430180. https://doi.org/10.1101/2021.02.08.430180
Shephard, E., McEwen, F. S., Earnest, T., Friedrich, N., Mörtl, I., Liang, H., Woodhouse, E., Tye, C., Bolton, P. F., & Team, T. S. (2022). Oscillatory neural network alterations in young people with tuberous sclerosis complex and associations with co-occurring symptoms of autism spectrum disorder and attention-deficit/hyperactivity disorder. Cortex, 146, 50–65.
Solinski, H. J., Dranchak, P., Oliphant, E., Gu, X., Earnest, T. W., Braisted, J., Inglese, J., & Hoon, M. A. (2019). Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science Translational Medicine, 11(500), eaav5464.
Solinski, H. J., Kriegbaum, M. C., Tseng, P.-Y., Earnest, T. W., Gu, X., Barik, A., Chesler, A. T., & Hoon, M. A. (2019). Nppb neurons are sensors of mast cell-induced itch. Cell Reports, 26(13), 3561–3573.
Vachez, Y. M., Tooley, J. R., Abiraman, K., Matikainen-Ankney, B., Casey, E., Earnest, T., Ramos, L. M., Silberberg, H., Godynyuk, E., Uddin, O., Marconi, L., Le Pichon, C. E., & Creed, M. C. (2021). Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption. Nature Neuroscience, 1–12. https://doi.org/10.1038/s41593-020-00772-7

Some Coding Projects

FED3 Viz

Software for visualizing rodent behavioral data from FED3 devices.

Sipper Viz

Software for visualizing rodent behavioral data from Sipper devices.

Song Learning

Machine learning for classifying songs by genre.